Behçet Disease

• Systemic vascular inflammatory disorder affecting skin, mucous membranes, eyes, lungs, GI tract and CNS. It is characterized by:
  • Mouth sores- aphthous ulcers usually first sign
  • Genital sores- (75%) small ulcers on scrotum or labia
  • Erythema Nodosum- painful red skin nodules
  • Also puss filled bumps in the skin
  • Arthritis
• Typically symptoms start in the 20's or 30's

• Ocular Inflammation (66%)
  • Conjunctivitis
  • Uveitis
    • Hypopion
    • Panuveitis with vasculitis
• Complications of uveitis
  • cataracts, synechiae, band keratopathy

• Inflammation of the brain or spinal cord
• blood clots, aneurism, GI vasculitis

• Unknown autoimmune disorder
• Associated with the HLA-B51/B5 allele
  • 57% of people with this genotype have Behçet syndrome

Clinical Key Monograph