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| ocular_complications_chemotherapeutic_agents [2024/05/17 14:16] – Scott Larson | ocular_complications_chemotherapeutic_agents [2025/06/14 02:59] (current) – [References] Scott Larson |
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| ==== MEK inhibitors ==== | ==== MEK inhibitors ==== |
| * Selumetinib | * Selumetinib, Binimetinib, Trametinib, Cobimetinib |
| * Blurred vision, diplopia, eyelid edema, subconjunctival hemorrhage, increased lacrimation, retinal pigment and epithelial detachment | * Blurred vision, diplopia, eyelid edema, subconjunctival hemorrhage, increased lacrimation |
| | * Retinal pigment epithelial detachment, Central serous-like retinopathy |
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| ====References==== | ====References==== |
| * {{::ocular_toxicity_of_mek_inhibitors_and_other_targeted_therapies.pdf |Ocular toxicities of MEK inhibitors and other targeted therapies. Stjepanovic et al. Annals of Oncology.Volume 27, Issue 6, June 2016, Pages 998-1005}} | * [[https://1drv.ms/b/c/31d83ae8e55e0542/ERC5LNJpRMBEuMqgnPkrivMBz0aY8tspvomR00t6YZzhng?e=BaC6F7|Ocular toxicities of MEK inhibitors and other targeted therapies. Stjepanovic et al. Annals of Oncology.Volume 27, Issue 6, June 2016, Pages 998-1005]] |
| * {{::clinical_and_morphologic_characteristics_of_mek_inhibitor-associated_retinopathy.pdf |Clinical and Morphological Characteristics of MEK Inhibitor-Associated Retinopathy. Francis, Jasmine H. et al. Ophthalmology. 2017-12, Vol.124 (12), p.1788-1798 }} | * [[https://1drv.ms/b/c/31d83ae8e55e0542/EYA8uzBJ-_BBiRnZReDu7NUBqsbAxKVJqHK3n-dqPKIwmw?e=DZwwKg |Clinical and Morphological Characteristics of MEK Inhibitor-Associated Retinopathy. Francis, Jasmine H. et al. Ophthalmology. 2017-12, Vol.124 (12), p.1788-1798]] |